Global Neuro-Infections Outcome Study (GNIOS)

GNIOS is a prospective, international, multi-centre observational study involving hospitals admitting both adult and paediatric patients with de novo brain or spine infections (not infections from previous surgery). The study is aimed at understanding the global burden and spectrum of infectious disease on surgical services and their outcomes. There are two components, a 60-day prospective cohort study to gather data on surgical consultations and procedures and a retrospective one-year cohort at selected sites to analyse seasonal variations. By identifying trends and key factors, this project seeks to provide comprehensive data on the surgical management and outcomes of CNS infections, highlighting regional differences and identifying areas for improvement. Despite the known global burden of infectious diseases, little is known about how this affects neurosurgical services. The findings will inform strategies to enhance surgical care and resource allocation, ultimately aiming to reduce morbidity and mortality associated with CNS infections globally. Your collaboration is essential to advancing this important field of research. Centres recruiting patients will be included as co-authors. The study is being run under the guidance of the NIHR ABSI group, co-led by Professor Tony Figaji (Cape Town) and Prof Peter Hutchinson (Cambridge).